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UMAP

Snapshot Proteomics™ for basic science

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UMAP™ is a broadly applicable tool for basic science that uses Snapshot Proteomics™ to reveal changes to the proteome of your manipulated cells or specific protein interactions of your purified protein samples. For example, if you provide experimentally manipulated cells, we can determine the changes in post-translational modification across ~20,000 human proteins.

 
The result is the novel discovery of wide range of physiologically relevant information, including modified proteins, substrates, and biochemical pathways. A single UMAP™ screen could potentially provide an entire career’s worth of leads and ideas.

 
With UMAP™ (and all of our services) you get far more than just the raw data. You will also receive:

  • bioinformatic analysis to reveal the underlying biology
  • a full report with detailed methods and explanations of results
  • a conference call with our scientists who will present their findings
  • unlimited technical support should additional questions arise

 

To get started with UMAP™, contact us so we can discuss your specific project or idea!

 

UMAP™ is an acronym for types of post-translational modifications: Ubiquitination, Methylation, Acetylation, and Phosphorylation.

 

    Examples of questions that UMAP™ has answered for clients:

    • Which kinases regulate my protein of interest (POI)?
    • Which phosphatases regulate my POI?
    • Is my POI a good target of pharmacological intervention?
    • What are the protein-protein interactions involving my POI?
    • What are the substrates of my E3?
    • What are the substrates of my deubiquitylase (DUB)?
    • What is the cellular response to a mutation/deletion/knockdown/overexpression of a gene of interest?
    • What is the cellular response to a specific environmental/growth condition, extracellular stress, or pharmacological intervention?
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